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侯云龙-博士-正高级工程师

发布时间:2025-02-27   浏览次数:0

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侯云龙,男,1976年10月出生,石家庄以岭药业股份有限公司以岭医药研究院副院长、新药评价中心药理部主任,正高级工程师,先后获得石家庄A类人才、河北省“百人计划”引进的海外高层次人才、石家庄市引进高层次科技创新创业人才等称号,被授予省级特聘专家称号。,主要从事创新药物研发方面研究。自2019年以来,以课题负责人身份获省部级项目资助5项,累积获得资助金额800余万元;以第一作者或通讯作者身份在国际知名杂志上发表论文20余篇,累计影响因子超200分;以中药连花清瘟治疗新冠肺炎的研究成果获得河北省科学技术奖一等奖,并参与一项关于连花清瘟药物代谢产物鉴定方法的发明专利。2022年获石家庄市政府授予的高层次科技创新创业人才一等奖。在人才培养方面,先后被聘为河北中医药大学博士研究生导师、河北医科大学硕士研究生导师及南京中医药大学硕士研究生导师,目前已经招生7名博士研究生和5名硕士研究生。
主持或承担课题项目
1.气络学说精气神理论指导中药抗衰老评价技术与整合机制研究,中华人民共和国科学技术部,国家重点研发计划“中医药现代化”重点专项课题,2023YFC3504300,400万,课题负责人,2023年11月至2026年10月。
2.基于气络学说精气神理论的中药抗衰老评价技术及产品开发,河北省科学技术厅,河北省省级科技计划资助,23379902L,90万元,课题负责人,2023年11月至2026年11月。
3.气络学说指导补肾填精药物八子补肾抗衰老研究,河北省科学技术厅,河北省重点研发计划项目,22372502D,50万元,课题负责人,2022年07月至2025年06月。
4.基于“时钟预测”及生物标记物锚定AI辅助“补肾填精”类抗衰老药物临床前及临床评价,石家庄市科学技术局,石家庄市“揭榜挂帅”制科技项目,231790133A,60万元,课题负责人,2023年06月至2026年06月。
5.石家庄市引进高层次科技创新创业人才项目,石家庄市科学技术局,07202203,200万元,课题负责人,2022年01月至2024年12月。
发表论文情况
1.Liu H,Wei G,Wang T, et al.Angelica keiskei water extract Mitigates Age-Associated Physiological Decline in Mice.[J]. Redox report:communications in free radical research,2024,29(1)2305036-2305036.
2.Qi H ,Ma H Q ,Feng W , et al.Glycyrrhetinic acid blocks SARS-CoV-2 infection by activating the cGAS-STING signalling pathway.[J].British journal of pharmacology,2024,181(20)3976-3992.
3.Xiaogang S ,Mengnan L ,Yawen L , et al.Bazi Bushen ameliorates age-related energy metabolism dysregulation by targeting the IL-17TNF inflammatory pathway associated with SASP[J].Chinese Medicine,2024,19(1)61-61.
4.Ma K ,Li M ,Song Y , et al.Bazi Bushen alleviates reproductive aging in aged male mice.[J].Chinese journal of natural medicines,2024,22(5)416-425.
5.Qi H ,Hou Y ,Han N , et al.Impairment of pulmonary microvascular endothelial cells The ground for COPD[J].Chinese medical journal,2024,
6.Wei R Y ,Hou L Y ,Yin J Y , et al.Tongxinluo Activates PI3KAKT Signaling Pathway to Inhibit Endothelial Mesenchymal Transition and Attenuate Myocardial Fibrosis after Ischemia-Reperfusion in Mice.[J].Chinese journal of integrative medicine,2024,30(7)608-615.
7.Zhang S ,Li M ,Chang L , et al.Bazi Bushen capsule improves the deterioration of the intestinal barrier function by inhibiting NLRP3 inflammasome-mediated pyroptosis through microbiota-gut-brain axis[J].Frontiers in Microbiology,2024,141320202-1320202.
8.Wang X ,Hao Y ,Yin Y , et al.Lianhua Qingke Preserves Mucociliary Clearance in Rat with Acute Exacerbation of Chronic Obstructive Pulmonary Disease by Maintaining Ciliated Cells Proportion and Protecting Structural Integrity and Beat Function of Cilia.[J].International journal of chronic obstructive pulmonary disease,2024,19403-418.
9.Li Z, Zhang Q, Gao Y, Wan F, Wang Y, Hou B, Cui W, Wang Y, Feng W, Hou Y. Luobitong Potentiates MTX's Anti-Rheumatoid Arthritis Activity via Targeting Multiple Inflammatory Pathways. J Inflamm Res. 2024 Jul 6;174389-4403. doi 10.2147JIR.S461093. PMID 38994468; PMCID PMC11236762.
10.Niu K ,Chang L ,Zhang R , et al.Bazi Bushen mitigates age-related muscular atrophy by alleviating cellular senescence of skeletal muscle[J].Journal of Traditional and Complementary Medicine,2024,14(5)510-521.
11.Xu Z ,Zhang Z ,Zhou H , et al.Bazi Bushen attenuates osteoporosis in SAMP6 mice by regulating PI3K-AKT and apoptosis pathways.[J].Journal of cellular and molecular medicine,2024,28(20)e70161.
12.Shen X ,Zhang X ,Li K , et al.Combined bacterial translocation and cholestasis aggravates liver injury by activation pyroptosis in obstructive jaundice[J].Heliyon,2024,10(16)e35793-e35793.
13.An X ,Xu W ,Zhao X , et al.Bazi Bushen capsule attenuates cardiac systolic injury via SIRT3SOD2 pathway in high-fat diet-fed ovariectomized mice[J].Heliyon,2024,10(11)e32159-.
14.Li R ,Deng H ,Han Y , et al.Therapeutic effects of Lianhua Qingke on COPD and influenza virus-induced exacerbation of COPD are associated with the inhibition of NF-κB signaling and NLRP3 inflammasome responses.[J].International immunopharmacology,2024,142(Pt B)113213.
15.Wang M ,Li T ,Li W , et al.Unraveling the neuroprotective potential of scalp electroacupuncture in ischemic stroke A key role for electrical stimulation.[J].Neuroscience,2024,562160-181.
16.Zhang S ,Li M ,Chang L , et al.Bazi Bushen capsule improves the deterioration of the intestinal barrier function by inhibiting NLRP3 inflammasome-mediated pyroptosis through microbiota-gut-brain axis[J].Frontiers in Microbiology,2024,141320202-1320202.
17.Xin Z ,Ziyu L ,Xilin X , et al.Huogu injection protects against SONFH by promoting osteogenic differentiation of BMSCs and preventing osteoblast apoptosis.[J].Cell and tissue research,2023,395(1)63-79.
18.Chi Z ,Mingye W ,Tongtong L , et al.Antidepressant-like effects of Jieyu Chufan capsules in the olfactory bulbectomy rat model.[J].Brain research,2023,1824148676-148676.
19.Zhang ,Li ,Wang , et al.Shensong Yangxin Capsule Reduces the Susceptibility of Arrhythmia in dbdb Mice via Inhibiting the Inflammatory Response Induced by Endothelium Dysfunction[J].Drug Design, Development and Therapy,2023,2023313-330.
20.Tao S ,Yuanyuan H ,Mingye W , et al.Sophoridine manifests as a leading compound for anti-arrhythmia with multiple ion-channel blocking effects.[J].Phytomedicine  international journal of phytotherapy and phytopharmacology,2023,112154688-154688.
21.Yuanyuan H ,Tao S ,Mingye W , et al.Dual targets of lethal apoptosis and protective autophagy in liver cancer with periplocymarin elicit a limited therapeutic effect.[J].International journal of oncology,2023,62(3)
22.Zhao L ,Xilin X ,Yiwei S , et al.Altered gut microbiota and metabolites profile are associated with reduced bone metabolism in ethanol-induced osteoporosis.[J].Cell proliferation,2022,55(7)e13245-e13245.
23.YuanYuan H ,WenWen C ,HuaiLin G , et al.Jinlida granules ameliorate the high-fat-diet induced liver injury in mice by antagonising hepatocytes pyroptosis.[J].Pharmaceutical biology,2022,60(1)274-281.