团队负责人：王巧（教授，博导）

博士，教授，博士生导师，河北医科大学药学院药物分析教研室主任，药物分析学科带头人。中国药学会药物分析专业委员会委员，河北省药学会药物分析与质量管理专业委员会副主任委员，河北省药学会中药分析学会副主任委员。主持国家自然科学基金、教育部重点研发计划、河北省高校百名优秀创新人才支持计划、河北省科技支撑计划、河北省自然科学基金和河北省国际合作等课题，获河北省科技进步二，三等奖，编写药物分析相关本科和研究生教材多部，制定河北省中药材质量标准和中药饮片炮制规范，完成药物研发质量研究工作多项。

团队骨干成员：

杜英峰（教授，博导），许慧君（教授，博导），王春英（教授，硕导），孙宇鹏（讲师，硕导）

研究方向：

1.中药质量和药效物质基础

2.药物分析新方法新技术

3.化学药和生物药物分析

4.临床药物分析和生物标志物

近五年获批主要科研项目

1.81973469，2020/01/01-2023/12/31，国家自然科学基金面上项目，毒性中药效/毒物质群同步研究模式的建立及其在雷公藤制剂质量评价中的应用，负责人：王巧，55万。

2.H2020206629，2021/02/01-2024/12/31，河北省自然科学基金面上项目，基于代谢组学整合PK-PD模型的级联网络模式研究苓桂术甘汤治疗心力衰竭的药效物质基础，负责人：王巧，10万。

3.H2023206206，2023/01/01-2025/12/31，基于“生物效应-菌群调节-机体代谢-药源成分”的干姜“生熟异治”机理研究，河北省自然科学基金中医药联合研究基金，负责人：许慧君，8万。

4.Z2022012，2022/01/01-2025/12/31，基于多维矩阵投影代谢组学体系的白头翁汤治疗溃疡性结肠炎物质基础与作用机制整合研究，河北省中医药管理局科研计划重大项目，负责人：许慧君，20万。

5.基于成分-效应-代谢组学的知母盐炙机理及肾靶向性的相关性研究（H2022206384），2022/01/01-2024/12/31，河北省自然基金中医药联合基金培育项目，负责人：杜英峰，10万元。

6.2025年河北省专精新特“小巨人”企业特派团-河北国龙科技有限公司特派团项目，2025/01-2027/12，负责人：杜英峰，3万元。

近三年发表主要论文

1.Yupeng Sun, Kaihui Zhou, Yuxin Wang, Ye Lin, Weiran Wang, Xue Xiong, Xiangru Zhao, Huinan Cui, Min Liang, Qiao Wang, Shengnan Yang, Li Li. Rapid and sensitive in-situ detection of malachite green and crystal violet in aquaculture using flexible SERS substrates via instant self-assembly. Food Chemistry,2025,489:144920.

2.Zhang, Xiaoguang; Zhang, Jia; Xun, Ge; Gao, Yanhua; Zhao, Jie; Fu, Yan; Su, Suwen; Kong, Dezhi; Wang, Qiao; Wang, Xu ; Alleviation effect of macrophage depletion on hepatotoxicity of triptolide: A new insight based on metabolomics and proteomics, Journal of Ethnopharmacology,2025, 343:119485.

3.Xi Tian, Qingfei Cui, Jinhuan Wei, Qian Zhang, Huiyi Zhang, Mengxin Yang,     Yiqi Xing, YukunNiu, Wenyu Li, Nan Wang, Yiran Jin*, Yingfeng Du*. Anemarrhenaasphodeloides Bunge-FritillariaCirrhosaeBulbus Herb Pair Alleviates Ovalbumin-Induced Asthma by Regulating Arachidonic Acid PathwayDrug Design, Development and Therapy. 2025,19: 4407.

4.Shilin Sun, Yuping Chen, Yu Zhang, YukunNiu, Mengxin Yang, XinmingJia, Yiqin song, Qingwei Dong, Xin Qi, Jiahui Ma, Qian Zhang, Yiran Jin* and Yingfeng Du*. A novel comprehensive strategy for research on wine-processed mechanism of cornifructus guided by variation in the chemical components and network analysis.BMC Complementary Medicine and Therapies. 2025,25:312. 

5.Xin-ming Jia, Han Hao, Qian Zhang, Meng-xin Yang, Nan Wang, Shi-lin Sun, Ze-nan Yang, Yi-ran Jin, Jing Wang, Ying-feng Du. The bioavailability enhancement and insight into the action mechanism of poorly soluble natural compounds from co-crystals preparation: oridonin as an example. Phytomedicine,2024,122:155179. 

6.Shilin Sun, KenanPeng, Bingkun Yang, Mengxin Yang, XinmingJia, Nan Wang, Qian Zhang, Dezhi Kong, Yingfeng Du. The therapeutic effect of wine-processed CorniFructus on chronic renal failure in rats through the interference with the LPS/IL-1-mediated inhibition of RXR function. Journal of Ethnopharmacology. 2024,321: 117511. 

7.Yanhua Gao, Qi Qian, Ge Xun, Jia Zhang, Shuo Sun, Xin Liu, Fangfang Liu,Jiachen Ge, Huaxing Zhang, Yan Fu, Suwen Su, Xu Wang, Qiao Wang. Integrated metabolomics and network analysis reveal changes in lipid metabolisms of tripterygium glycosides tablets in rats with collagen induced arthritis. Computational and Structural Biotechnology Journal, 2023,21:1828. 

8.Jia Chen Ge, Qi Qian, YanHua Gao, YiFan Zhang, YingXuan Li, Xu Wang, Yan Fu, YuMei Ma, Qiao Wang. Toxic effects of Tripterygium glycoside tablets on the reproductive system of male rats by metabolomics, cytotoxicity, and molecular docking.Phytomedicine,2023,114:154813.

9.Shanshan Su , Guiren Xue , Jiawei Shang , Pengfei Yan , Jianxin Wang , Chengye Yan , Jiaxi Li , Xue Xiong , Huijun Xu. Computational method for rapid screening of the metabolites of Pulsatilla chinensis in rats using UHPLC-Q-TOF/MS combined with mass spectrum-based orthogonal projection. Journal of Pharmaceutical and Biomedical Analysis, 2023, 229: 115345. 

10.Jiawei Shang, Jianxin Wang, Pengfei Yan, Chengye Yan, Jiaxi Li, Jiahao Li, Xin Yong, Qiao Wang, Xue Xiong, Huijun Xu, Integrative strategy for quality control of Radix Bupleuri based on non-targeted metabolomic profiling and molecular networking. Analytical and Bioanalytical Chemistry, 2023, 415: 961.